President-elect Joe Biden has pledged to rejoin the Paris climate accord and the World Health Organization on the first day of his presidency. After four years of retreat from globalization, free trade, and multilateralism, the US appears set to recast the global order by reinvesting in the types of global alliances and multilateral cooperation that shaped – until recently – much of the liberal international order since the post–World War II era. Despite the rise of protectionism in recent times, the argument for deepening economic integration remains compelling. America’s foreign policy under a Biden presidency may witness the most significant shift since 9/11, and perhaps since the end of the Cold War. This will have major implications for US-Africa trade and investment ties.